AI Summary: This study maps the birth and maturation of the mouse nose cell-by-cell during pregnancy. Using single-cell sequencing on nearly 200,000 cells, researchers tracked the exact moments when stem cells decide to become smell-detecting neurons or protective lining cells.
The mammalian nasal cavity is a complex structure hosting the olfactory system, respiratory epithelium, and various specialized glands, yet the temporal logic of its development remains largely unmapped. We present a high-resolution single-cell RNA sequencing (scRNA-seq) atlas of mouse nasal development, comprising 183,247 cells collected across embryonic days E10.5 to E18.5. We identify the molecular signatures of emerging olfactory sensory neurons, supporting cells, and the diversification of the non-sensory respiratory lineage. Our atlas reveals the transcriptional waves governing the transition from progenitors to mature cell types and provides a framework for understanding congenital nasal malformations and olfactory defects.
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