AI Summary: This study provides the most comprehensive multi-omics resource to date for the developing human hindbrain across the entire lifespan. By combining single-nucleus RNA-seq and ATAC-seq, the researchers mapped the trajectory of over one million cells to uncover specific gene regulatory networks.
The human hindbrain is a phylogenetically ancient region responsible for vital physiological functions and sensory-motor coordination, yet its developmental logic remains poorly understood. We present an integrated single-nucleus multi-omics atlas of the developing human hindbrain, encompassing 594,817 transcriptomic and 422,568 chromatin accessibility profiles from embryonic to adult stages. We identify lineage-specific regulatory networks and temporal shifts in gene expression across distinct neuronal and glial populations. Our atlas reveals the molecular programs underlying the diversification of the cerebellum and brainstem, providing a resource for understanding neurodevelopmental disorders and pediatric cancers originating in these regions.
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