SIN-3 coregulator maintains adaptive capacity to different diets through vitamin B12

ABSTRACT

Using C. elegans as a model, the authors identify SIN-3 as a key epigenetic regulator that allows organisms to adapt to dietary changes by modulating vitamin B12 metabolism. The study reveals how SIN-3 ensures metabolic resilience and healthy aging across varied nutrient environments. The findings have potential implications for understanding human metabolic adaptation and longevity.