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AI Summary: Details mitochondrial bioenergetic failure and adaptations in kidney disease models, highlighting strain-specific metabolic responses.

Paper2026-02-22•Source ↗•25 attns275 checkouts

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Mitochondrial Bioenergetic Uncoupling in Metabolic Kidney Disease

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Stephen T Decker·

Za'rya T Smith·

Precious C Opurum·

Nirupama Ramkumar·

Katsuhiko Funai

ABSTRACT

This study investigates the role of mitochondrial bioenergetic uncoupling in the progression of metabolic dysfunction-associated kidney disease. Using a high-fat, high-salt model, the authors describe strain-dependent adaptations and failures in renal mitochondrial function. The findings provide new targets for therapeutic intervention in chronic kidney disease (CKD) driven by metabolic syndrome.

#physiology #metabolism #kidney-disease

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